Aliskiren may enhance the nephrotoxic effect of angiotensin ii receptor blockers. Aliskiren has good water solubility and low lipophilicity, and is resistant to biodegradation by peptidases in the intestine, blood circulation, and the liver. Combined use in other patients should be avoided, particularly when crcl is less than 60 ml. Aliskiren use with aceis or arbs in patients with diabetes is contraindicated. Hypersensitivity reactions eg, anaphylactic reactions and angioedema of the face, extremities, lips, tongue, glottis andor larynx have been reported in patients treated with aliskiren and has necessitated hospitalization and intubation. Aliskiren is the newest antihypertensive drug and the first orally active direct renin inhibitor to become available for clinical use.
Aliskirencontaining bp drugs in combination with ace inhibitors and arbs are now contraindicated for patients with diabetes based on the aborted altitude study, the fda announced. Clinical data have substantiated that the antihypertensive effectiveness of aliskiren is similar to that of the other major antihypertensive agents. Indicaciones hipertension arterial, especialmente en pacientes con intolerancia a iecas. The invention discloses a kind of preparation method of aliskiren, aliskiren is prepared using r tbutyl sulfonamide and compound viii, the chiral induction effect of r tbutyl sulfonamide is utilized to build second required chiral centre, and solve build below second, third, four chiral centres when need column chromatography for separation the problem of, so that the preparation method. Aliskiren, an orally effective renin inhibitor, provides antihypertensive efficacy alone and in combination with valsartan article in american journal of hypertension 201. Aliskiren tekturna, rasilez contraindicated with ace. While used for high blood pressure, other better studied medications are typically recommended due to concerns of higher side effects and less evidence of benefit. Aliskiren combined with losartan in type 2 diabetes and nephropathy. Pdf aliskiren combined with losartan in type 2 diabetes and. Pdf aliskiren combined with losartan in type 2 diabetes.
Aliskiren tekturna gets new warning and contraindication. Tablets are imprinted with nvr on one side and il, iu, on the other side of the 150 mg and 300 mg tablets, respectively. When used as a singleagent treatment, aliskiren rasilez was shown to provide similar efficacy in blood pressure reduction as ace inhibitors, angiotensin ii receptor blockers, betablockers and thiazide diuretics. Aliskiren brand names tekturna and rasilez is the first in a class of drugs called direct renin inhibitors. Sica, in textbook of nephroendocrinology second edition, 2018. Nov 28, 2017 tekturna tablets are supplied as a lightpink, biconvex round tablet containing 150 mg of aliskiren, and as a lightred biconvex ovaloid tablet containing 300 mg of aliskiren. Tekturna aliskiren dosing, indications, interactions.
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